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Deep, targeted upcoming-technology sequencing has exposed that subclonal mutations (i.e., All those current in just a fraction of tumor cells) may be detected for all driver genes and so are connected to quick disease development and bad final result.eleven–thirteen This is especially related for TP53
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This methylation profile is already acquired at the MBL stage3 and continues to be rather secure over time. Nevertheless, some CLL have intratumor variability in particular locations, which may alter the expression of several genes and aid tumor evolution.71 Of note, this variability is greater in MBL77 U-CLL SITUS JUDI MBL77 than in M-CLL which is linked to growing number of subclones.7,seventy one
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